Patrick Henry Hughes was born March 10, 1988 to Patrick John and Patricia Hughes. Upon his delivery, the medical staff noticed physical anomalies. These were diagnosed as bilateral anophthalmia with pterygium syndrome and congenital bilateral hip dysplasia. His father, Patrick John Hughes, introduced him to the piano at the age of nine months. Patrick has studied piano in the years since and later began the study of trumpet. He has two younger brothers, Jesse and Cameron.
Patrick Henry's national fame began in 2006 while a student at the University of Louisville. At the suggestion of Louisville's marching band director, Dr. Greg Byrne, Patrick Henry joined the Louisville Marching Band, playing trumpet while his father pushed him in his wheelchair through the marching routines. This visible commitment attracted increasing crowd and media attention throughout the fall football season, and the pair of Patricks were featured in a variety of television and newspaper coverage. Patrick Henry was subsequently invited to play piano and sing in musical performances throughout the country, including two performances at the Grand Ole Opry, and onstage performances with Pam Tillis, Lonestar, Lane Brody, Chad Brock, Faith Hill, and Bryan White. Also in 2007 he played solo trumpet on stage in performance with the Louisville Orchestra.
Hughes graduated from Atherton High School, where he participated in the International Baccalaureate program and was a member of National Honor Society. He has graduated from the University of Louisville, magna cum laude where he majored in Spanish and played trumpet in the marching band.
In November 2007, the members of the Hughes family were chosen to be the recipients of a complete home renovation for the show Extreme Makeover: Home Edition. The episode aired on February 15, 2008. His family competed on Family Feud and Patrick John recently competed on Who Wants to Be a Millionaire.